SML1740

FIN56

≥98% (HPLC)

• Synonim(y): N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
• Wzór empiryczny (zapis Hilla): C₂₅H₃₁N₃O₅S₂
• Numer CAS: 1083162-61-1
• Masa cząsteczkowa: 517.66
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: [S](=O)(=O)(NC5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)NC4CCCCC4)C2N=O
• InChI: 1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,25,27-28H,1-10H2
• InChI key: OYLSCKVHQYAZEE-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 has an EC₅₀ value of 240 nM, and is believed to act though two separate pathways. The first requires the enzymatic activity of acetyl-CoA carboxylase (ACC),and results in degradation of glutathione peroxidase 4 (GPX4), which acts as a negative regulator of ferroptosis by reducing lipid hydroperoxides. The second pathway involves FIN56 binding to and activing squalene synthase, which leads to coenzyme Q10 depletion.

FIN56 is a specific inducer of ferroptosis.

Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable