SML1795

Tenofovir

≥98% (HPLC), DNA chain terminator, powder

• Synonim(y): (R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA
• Wzór empiryczny (zapis Hilla): C₉H₁₄N₅O₄P
• Numer CAS: 147127-20-6
• Masa cząsteczkowa: 287.21
• UNSPSC Code: 51111800
• PubChem Substance ID: 329826070
• NACRES: NA.77
• MDL number: MFCD00943794
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Tenofovir, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -20 to -26°, c = 0.5 in 1 M HCl
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
• InChI: 1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
• InChI key: SGOIRFVFHAKUTI-ZCFIWIBFSA-N

Opis

Biochem/physiol Actions

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription.

Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention.

Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable