SML1900

Sobetirome

≥98% (HPLC), thyroid hormone receptor (TR) β and TRα agonist, powder

• Synonim(y): 2-[4-[[4-Hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]acetic acid, 3,5-Dimethyl-4-(4′-hydroxy-3′-isopropylbenzyl)phenoxyacetic acid, GC 1, GC-1
• Wzór empiryczny (zapis Hilla): C₂₀H₂₄O₄
• Numer CAS: 211110-63-3
• Masa cząsteczkowa: 328.40
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Sobetirome, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O(CC(=O)O)c1cc(c(c(c1)C)Cc2cc(c(cc2)O)C(C)C)C
• InChI: 1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)
• InChI key: QNAZTOHXCZPOSA-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action.

Sobetirome is an orally active and potent agonist at thyroid hormone receptor (TR) β and TRα that displays selective tissue action. Sobetirome is devoid of thyrotoxic adverse effects on the heart, bone, and skeletal muscle.

Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3