SML2774

KDOAM25 hydrochloride hydrate

≥98% (HPLC)

• Synonim(y): 2-[[[2-[2-(Dimethylamino)ethyl-ethyl-amino]-2-oxidanylidene-ethyl]amino]methyl]pyridine-4-carboxamide hydrochloride hydrate, 2-[[[2-[2-(Dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxamide hydrochloride hydrate, KDOAM-25 hydrochloride hydrate
• Wzór empiryczny (zapis Hilla): C₁₅H₂₅N₅O₂ · xHCl · yH₂O
• Masa cząsteczkowa: 307.39 (anhydrous free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD30146416
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: N(CCN(CC)C(=O)CNCc1nccc(c1)C(=O)N)(C)C
• InChI key: PNFMVADNCOGWME-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC₅₀ values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

Selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable