SML2780

ML402

≥98% (HPLC)

• Synonim(y): N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide, N-[2-(4-Chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide
• Wzór empiryczny (zapis Hilla): C₁₄H₁₄ClNO₂S
• Numer CAS: 298684-44-3
• Masa cząsteczkowa: 295.78
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD01990273
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: ClC1=CC=C(OCCNC(C2=CC=CS2)=O)C(C)=C1
• InChI: 1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
• InChI key: RULQUKFOBAPKKR-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels

ML402 is a selective activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) potassium channels. It was used to determine a cryptic selectivity filter binding site of the K2P2.1 (TREK-1) channel, designated the K2P modulator pocket. This binding pocket stabilizes an active "leak-mode" conformation, binding small-molecule activators that restrict the mobility of the selectivity filter and surrounding structure.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable