SML2885

Ac-SDKP trifluoroacetate

≥95% (HPLC)

• Synonim(y): Ac-SDKP-OH trifluoroacetate, Ac-Ser-Asp-Lys-Pro-OH trifluoroacetate, AcSDKP trifluoroacetate, Goralatide trifluoroacetate, N-acetyl-L-seryl-L-a-aspartyl-L-lysyl-L-proline trifluoroacetate, N-acetyl-Ser-Asp-Lys-Pro-OH trifluoroacetate, Tβ4 (1-4) trifluoroacetate, Thymosin β4 (1-4) trifluoroacetate
• Wzór empiryczny (zapis Hilla): C₂₀H₃₃N₅O₉ · xC₂HF₃O₂
• Numer CAS: 1796568-94-9
• Masa cząsteczkowa: 487.50 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: lyophilized powder

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: lyophilized powder
• color: white to off-white
• storage temp.: −20°C

Opis

Biochem/physiol Actions

Originally characterized as a "spleen colony-forming units (CFU-S) inhibitor" for its activity against hematopoietic pluripotent stem cell proliferation, Ac-SDKP (Goralatide) is an immunomodulatory and pro-angiogenic tetrapeptide derived from the N-terminal end of thymosin β4 (Tβ4 aa 1-4) via sequential enzymatic actions of meprin-α and prolyl-oligopeptidase (POP), while angiotensin converting enzyme (ACE) mediates Ac-SDKP degradation. In animal heart, kidney and brain injury studies, Ac-SDKP ameliorates end-organ damage by promoting angiogenesis, as well as by reducing inflammation and fibrosis.

Thymosin β4 (Tβ4)-derived immunomodulatory and pro-angiogenic peptide with in vivo anti-inflammatory and anti-fibrotic efficacy.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable