SML2952

Tasisulam

≥98% (HPLC)

• Synonim(y): LY 573636, LY-573636, LY573636, N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide, N-(5-Bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzamide, N-[(5-Bromo-2-thienyl)sulfonyl]-2,4-dichlorobenzamide
• Wzór empiryczny (zapis Hilla): C₁₁H₆BrCl₂NO₃S₂
• Numer CAS: 519055-62-0
• Masa cząsteczkowa: 415.11
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD11973637
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(NC(=O)c2c(cc(cc2)Cl)Cl)c1[s]c(cc1)Br
• InChI: 1S/C11H6BrCl2NO3S2/c12-9-3-4-10(19-9)20(17,18)15-11(16)7-2-1-6(13)5-8(7)14/h1-5H,(H,15,16)
• InChI key: WWONFUQGBVOKOF-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

RNA binding motif protein 39 (RBM39; CAPERα, HCC1) degradation-inducing SPLAM (SPLicing inhibitor sulfonAMide).

Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) that bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC₅₀ = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable