SML3112

cis-22a

≥98% (HPLC)

• Synonim(y): 1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine, trifluoroacetate (1:2), cis-1-(4-(3-Methylphenyl)cyclohexyl)-4-((pyridin-4-yl)methyl)piperazine, trifluoroacetate (1:2)
• Wzór empiryczny (zapis Hilla): C₂₂H₂₉N₃ · 2CF₃CO₂H
• Numer CAS: 1819366-84-1
• Masa cząsteczkowa: 563.53
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32160702
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
• InChI key: UMKPISXYUQWXJJ-XWOHEVPJSA-N

Opis

Biochem/physiol Actions

Potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor that selectively inhibits the growth of TrpV6-expressing, but not TrpV6-negative cancer cultures.

cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2⁺ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable