SML3130

SHetA2

≥98% (HPLC)

• Synonim(y): 1-(4-Nitrophenyl)-3-(2,2,4,4-tetramethylthiochroman-6-yl)thiourea, N-(3,4-Dihydro-2,2,4,4-tetramethyl-2H-1-benzothiopyran-6-yl)-N′-(4-nitrophenyl)thiourea, NSC 726189, NSC-726189, NSC726189, Sulfur Heteroarotinoid A2
• Wzór empiryczny (zapis Hilla): C₂₀H₂₃N₃O₂S₂
• Numer CAS: 361483-66-1
• Masa cząsteczkowa: 401.55
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32160703
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S=C(NC1=CC=C2SC(C)(CC(C)(C)C2=C1)C)NC(C=C3)=CC=C3[N+]([O-])=O
• InChI: 1S/C20H23N3O2S2/c1-19(2)12-20(3,4)27-17-10-7-14(11-16(17)19)22-18(26)21-13-5-8-15(9-6-13)23(24)25/h5-11H,12H2,1-4H3,(H2,21,22,26)
• InChI key: FWWKIYPMUZVMQG-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Orally available chemopreventive fexible heteroarotinoid (Flex-Het) that induces cancer apoptosis in cultures and in vivo independent of retinoic acid receptor (RAR).

SHetA2 is an orally available chemopreventive fexible heteroarotinoid (Flex-Het) that inhibits cancer growth in cultures (OVCAR-3/SK-OV-3/Caov-3 GI50 = 3.9/4.1/7.0 μM) and in vivo (60-100 mg/kg SiHa xenograft mice) via apoptosis induction independent of retinoic acid receptor (RAR). SHetA2 is reported to bind heatshock proteins HSPA5 (GRP78, BiP), HSPA8 (HSC70, HSP73, HSPA10), HSPA9 (GRP75), resulting in cyclin D1 degradation.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable