SML3283

T-0080

≥98% (HPLC)

• Synonim(y): 3-(2-Hydroxy-5-methylphenyl)-5-(tetrahydro-2H-pyran-4-yl)-4-(4-(trifluoromethyl)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one, T 0080, T0080
• Wzór empiryczny (zapis Hilla): C₂₄H₂₂F₃N₃O₃
• Masa cząsteczkowa: 457.44
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1N(C2CCOCC2)C(C3=CC=C(C(F)(F)F)C=C3)C4=C(C5=C(O)C=CC(C)=C5)NN=C41
• InChI: 1S/C24H22F3N3O3/c1-13-2-7-18(31)17(12-13)20-19-21(29-28-20)23(32)30(16-8-10-33-11-9-16)22(19)14-3-5-15(6-4-14)24(25,26)27/h2-7,12,16,22,31H,8-11H2,1H3,(H,28,29)
• InChI key: NLNJUYHGBAJDBQ-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist with therapeutic efficacy in murine intracerebral hemorrhage (ICH) models in vivo.

T-0080 is a blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist that effectively inhibits fMLF-dependent response in human and murine neutrophils cultures (10 nM fMLF-induced human neutrophil Ca2+ response IC50 = 0.85 μM) and attenuates brain edema and improved neurological outcomes in murine intracerebral hemorrhage (ICH) models in vivo (5 mg/kg via daily i.p.) with no short-term adverse effects (up to 2 g/kg p.o.).

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable