SML3337

CBR-470-1, racemic

≥98% (HPLC)

• Synonim(y): (± )-3-((4-chlorophenyl)sulfonyl)-4-(isobutylamino)tetrahydrothiophene 1,1-dioxide, 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel- (ACI)
• Wzór empiryczny (zapis Hilla): C₁₄H₂₀ClNO₄S₂
• Numer CAS: 2416095-06-0
• Masa cząsteczkowa: 365.90
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD31735115
• eCl@ss: 32160702
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2%, clear
• storage temp.: 2-8°C

Opis

Biochem/physiol Actions

CBR-470-1 is an Inhibitor of the glycolytic enzyme PGK1 that induces Nrf2 activity. PGK1 inhibition results in acculumation of methylglyoxalyl (MGO), a toxic, reactive metabolite removed by other enzymes. The accumulated MGO then irreversibly reacts with Keap1 forming inactive Keap1 dimers, resulting in accumulation of Nrf2.

Inhibitor of the glycolytic enzyme PGK1 inducing Nrf2 activity

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable