SML3362

YM-244769 dihydrochloride

≥98% (HPLC)

• Synonim(y): N-​[(3-​Aminophenyl)​methyl]​-​6-​[4-​[(3-​fluorophenyl)​methoxy]​phenoxy]​-3-​pyridinecarboxamide dihydrochloride, N-(3-Aminobenzyl)-6-{4-[3-fluorobenzyl)oxy]phenoxy} nicotinamide dihydrochloride
• Wzór empiryczny (zapis Hilla): C₂₆H₂₂FN₃O₃·2HCl
• Numer CAS: 1780390-65-9
• Masa cząsteczkowa: 516.39
• UNSPSC Code: 51111800
• NACRES: NA.21
• MDL number: MFCD28160863
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to pink
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4
• InChI: 1S/C26H22FN3O3/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18/h1-14,16H,15,17,28H2,(H,30,31)
• InChI key: JZMLHJRKSJXARY-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3

YM-244769 hydrochloride is a potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3. It inhibits the Ca2+ entry mode of NCX more potently than the Ca2+ exit mode. YM-244769 exhibits protection in various hypoxic/ischemic cell injury models with low cell toxicity.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable