SML3690

Serodolin

≥98% (HPLC)

• Synonim(y): 1-(5-(4-(4-Fluorophenyl)piperazin-1-yl)pentyl)-1H-benzo[d]imidazol-2(3H)-one, 1-[5-[4-(4-Fluorophenyl)-1-piperazinyl]pentyl]-1,3-dihydro-2H-benzimidazol-2-one
• Wzór empiryczny (zapis Hilla): C₂₂H₂₇FN₄O
• Numer CAS: 1814929-81-1
• Masa cząsteczkowa: 382.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1NC2=C(N1CCCCCN3CCN(CC3)C4=CC=C(C=C4)F)C=CC=C2

Opis

Biochem/physiol Actions

β-arrestin-biased 5-HT7-selective agonist with antagonist/inverse agonist activity against Gs signaling and in vivo antinociceptive efficacy in mouse pain models.

Serodolin is a β-arrestin-biased, 5-HT7-selective 5-hydroxytryptamine receptor agonist (5HT7/2A/1A/6 Ki = 6.2/19/454/1224 nM) that induces ERK activation through a β-arrestin-dependent signaling mechanism that requires c-SRC activation (309% of basal pErk in 5HT7-transfected HEK293 post 2-15 min 10 μM treatment) while acting as an antagonist/inverse agonist against Gs signaling (IC50 = 14 & 5 nM, respectively, against basal and 10 nM 5-CT-induced cAMP production in 5HT7-transfected HEK293). Serodolin exhibits antinociceptive efficacy in response to inflammatory, thermal, and mechanical stimulation in mice in vivo (0.1-10 mg/kg s.c.).

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable