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Informacje o tej pozycji
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
SMILES string
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N(C)C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
Biochem/physiol Actions
DMHCA, a synthetic oxysterol, is an orally active liver X receptor (LXR) agonist (LXRα/β EC50 = 2 µM by reporter assays using respective CV-1 transfectants; LXRα/β Ki = 130/100 nM) that, unlike GW3965 & T0901317, preferentially induces ATP-binding cassette transporter ABCA1 gene transcriptional activation over that of SREBP-1c both in vitro and in mice in vivo. Long-term DMHCA administration significantly reduces lesion formation in male and female apoE-deficient mice (80 mg/kg/day via chow diet) without increasing hepatic triglyceride (TG) levels.
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Ta pozycja | |||
|---|---|---|---|
| description ≥98% (HPLC) | description Avanti Research™ - A Croda Brand 700125P, powder | description ≥98% (HPLC), powder | description A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα). |
| form powder | form powder | form powder | form solid |
| assay ≥98% (HPLC) | assay >99% (TLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. -10 to -25°C | storage temp. −20°C | storage temp. - | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility - | solubility DMSO: ≥20 mg/mL | solubility ethanol: 50 mg/mL, DMSO: 50 mg/mL |
| color white to beige | color - | color white | color light beige |
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Klasa składowania
11 - Combustible Solids
WGK
WGK 3
Temperatura zapłonu (°F)
No data available
Temperatura zapłonu (°C)
No data available
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