SML4164

ATN-161 trifluoroacetate salt

≥95% (HPLC), (Powder or Lyophilized powder or film), integrin α5β1receptor antagonist

• Synonim(y): 1-Acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-aspartamide trifluoroacetate salt, Ac-PHSCN-NH2 trifluoroacetate salt, Ac-Pro-His-Ser-Cys-Asn-NH2, PHSCN trifluoroacetate salt
• Wzór empiryczny (zapis Hilla): C₂₃H₃₅N₉O₈S · xC₂HF₃O₂
• Numer CAS: 262438-43-7
• Masa cząsteczkowa: 597.64 (free base basis)
• NACRES: NA.21
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: (Powder or Lyophilized powder or film)
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C
• SMILES string: O=C([C@H]1N(C(C)=O)CCC1)N[C@@H](CC2=CN=CN2)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O

Opis

Application

ATN-161 trifluoroacetate salt may be used in studies focusing on angiogenesis and cancer research, particularly in the development of models assessing tumor growth and metastasis. It may also be used as a fluorescent probe in research to study cellular processes and interactions due to its ability to bind to integrins.

Biochem/physiol Actions

ATN-161, an antagonist of the integrin α5β1 receptor, is a non-RGD-based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 exhibits antiangiogenic and antitumor activity. This noncompetitive inhibitor of the fibronectin PHSRN sequence has the potential to disrupt the function of various integrins involved in tumor angiogenesis and metastasis. It can inhibit the interaction between the SARS-CoV-2 spike protein and its host binding partners.

Disclaimer

Hygroscopic

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable