SML4314

Procyanidin B1

≥98% (HPLC)

• Synonim(y): (+)-Procyanidin B1, (2R,2′R,3R,3′S,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-3,3′,4,4′-tetrahydro[4,8′-bi-2H-1-benzopyran]-3,3′,5,5′,7,7′-hexol, (-)-Epicatechin-(4β-8)-(+)-catechin, Epicatechin 4β-8 catechin, Proanthocyanidin B1, PCB1, PB1
• Wzór empiryczny (zapis Hilla): C₃₀H₂₆O₁₂
• Numer CAS: 20315-25-7
• Masa cząsteczkowa: 578.52
• UNSPSC Code: 41116107
• eCl@ss: 32120505
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

Procyanidin B1, a natural biflavonoid, functions as a potent antioxidant and anti-inflammatory agent, mitigating oxidative stress and inflammation associated with chronic diseases. It exhibits multi-target activity, directly interacting with enzymes like Caspases and COX-2, the Kv10.1 ion channel (IC50 ~10 µM), and the TLR4/MD-2 complex, while inhibiting key signaling pathways including NF-κB, MAPK, and PI3K/Akt. Mechanistically, Procyanidin B1 promotes cancer cell apoptosis (activating Caspase-3, upregulating Bax), potentially regulating ferroptosis via the Nrf2/HO-1/Keap-1 pathway, induces cell cycle arrest (downregulating Cyclins), suppresses inflammatory gene expression (TNF-α, IL-6), provides neuroprotection (effective at 50-100 µM vs Aβ), and regulates metabolic pathways. In vitro and in vivo evidence supports its efficacy in reducing tumor growth and inflammation, demonstrated by decreased biomarkers like TNF-α, IL-6, and Ki67, and increased activated Caspase-3, although systemic delivery faces challenges due to its low cell permeability and oral bioavailability as an intact dimer.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable