SML4345

AZD3965

≥98% (HPLC)

• Synonim(y): 5-​[[(4S)​-​4-​Hydroxy-​4-​methyl-​2-​isoxazolidinyl]​carbonyl]​-​3-​methyl-​1-​(1-​methylethyl)​-​6-​[[5-​methyl-​3-​(trifluoromethyl)​-​1H-​pyrazol-​4-​yl]​methyl]​-thieno[2,​3-​d]​pyrimidine-​2,​4(1H,​3H)​-​dione, AZD 3965, AZD-3965
• Wzór empiryczny (zapis Hilla): C₂₁H₂₄F₃N₅O₅S
• Numer CAS: 1448671-31-5
• Masa cząsteczkowa: 515.51
• MDL number: MFCD28963899
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

AZD3965 is an orally bioavailable, potent and specific monocarboxylate transporter 1 (MCT1) inhibitor that causes increase of intracellular lactate, reduces cell proliferation and COR-L103 tumor growth in mice. AZD3965 treatment most likely induces a necrotic cell death, in hypoxic COR-L103 and NCI-H1048 tumors.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids