SML4382

Tryptophan-conjugated cholic acid

≥98% (HPLC)

• Synonim(y): CA-Trp, N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]tryptophan, Trp-CA
• Wzór empiryczny (zapis Hilla): C₃₅H₅₀N₂O₆
• Numer CAS: 1630745-39-9
• Masa cząsteczkowa: 594.78
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

Tryptophan-conjugated cholic acid (Trp-CA), a novel microbial amino-acid-conjugated bile acid, is an endogenous ligand for orphan GPCR MRGPRE (Mas-related G protein-coupled receptor family member E), revealing a non-itch glucose-regulatory function. CA-Trp activates MRGPRE (10 µM), initiating intestinal L-cell GLP-1 secretion via dual Gs-cAMP (EC50 = 9.6 µM) and β-arrestin-1-ALDOA pathways. The latter involves β-arrestin-1 recruitment and ALDOA phosphorylation. In vivo, oral Trp-CA improves glucose tolerance and ameliorates obesity in HFD-fed diabetic mice, highlighting its potential as a gut-localized T2D therapeutic.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable