SML4458

Lithocholic acid High Purity

≥98% (HPLC)

• Synonim(y): 3α-Hydroxycholanic acid; (3α,5β)-3-Hydroxycholan-24-oic acid, 17β-(1-Methyl-3-carboxypropyl)etiocholan-3α-ol; 3α-Hydroxy-5β-cholan-24-oate
• Wzór empiryczny (zapis Hilla): C₂₄H₄₀O₃
• Numer CAS: 434-13-9
• Masa cząsteczkowa: 376.57
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

Lithocholic acid (LCA), a secondary bile acid absorbed into the bloodstream and transported to muscle, acts as a TGR5 agonist and endogenous calorie restriction mediator, indirectly activating SIRT1 via TUB Like Protein 3 (TULP3) to engage AMPK through v-ATPase inhibition. This cascade improves metabolic parameters and stress resistance, raises GLP-1, and notably exhibits antineoplastic effects in pancreatic adenocarcinoma by inducing oxidative/nitrosative stress via CAR, FXR, and VDR nuclear receptors, inhibiting proliferation, EMT, and stem cell markers while upregulating mitochondrial oxidative phosphorylation. LCA extends lifespan in model organisms and enhances grip strength and insulin sensitivity in aged mice, underscoring its broad therapeutic potential in aging and oncology.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable