The amino acid sequence for Tau-441 human is as follows: MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
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T0576
Tau-441 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Synonim(y):
Human Tau Protein, Tau Protein
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
50 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3320,00 zł |
Informacje o tej pozycji
Form:
lyophilized powder
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
45.9 kDa
3320,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócbiological source
human
Quality Segment
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized powder
mol wt
45.9 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... MAPT(4137)
General description
Tau-441 human, recombinant, is an isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N). Tau is a family of neuronal microtubule-associated proteins. Tau, a phosphoprotein is considered as an important microtubule associated protein (MAP) of a mature neuron. The 2N4R tau consists of 441 amino acids (tau441) and is considered as the largest size human brain tau. In human brain, tau is present in six molecular isoforms.
The gene microtubule associated protein tau (MAPT) is localized on human chromosome 17q21.3. It is expressed in neurons, more specifically in axons.
Application
Human Tau-441 has been used to study the effects of tau on neuropathological changes in Alzheimer′s disease.
Tau-441 human has been used to study its effects on mitochondrial transport velocities found in glial cells.
Biochem/physiol Actions
Microtubule associated protein tau (MAPT) plays an important role in the assembly and maintenance of the microtubule structure. Loss of expression of MAPT results in developmental delay and learning disability. The protein has been associated with pathology of Alzheimer′s disease (AD).
Tau promotes assembly and stabilizes neuronal microtubules under normal physiological conditions.
Isoform of Tau, variant 2N4R, having 4 microtubule binding repeats (R) and 2 amino terminal inserts (N)
Preparation Note
Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
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Ta pozycja | |||
|---|---|---|---|
| description recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder | description recombinant, lyophilized powder, expressed in HEK 293 cells, ≥95% (SDS-PAGE) | description recombinant, expressed in E. coli, ≥85% (SDS-PAGE), lyophilized powder | description recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder |
| recombinant expressed in E. coli | recombinant expressed in HEK 293 cells | recombinant expressed in E. coli | recombinant expressed in E. coli |
| assay ≥90% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥85% (SDS-PAGE) | assay ≥90% (SDS-PAGE) |
| biological source human | biological source human | biological source human | biological source human |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| mol wt 45.9 kDa | mol wt calculated mol wt 50.3 kDa (including c-terminal His and V5 tags), observed mol wt 70-100 kDa by SDS-PAGE (The protein migrates as a 70-110 kDa protein on SDS-PAGE due to glycosylation) | mol wt 42.6 kDa | mol wt 39.7 kDa |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
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Klasa składowania
11 - Combustible Solids
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
PPE (środki ochrony indywidualnej)
Eyeshields, Gloves, type N95 (US)
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Could you please provide the amino acid sequence for Tau-441 human (T0576) ?
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