T3580

Toyocamycin

≥98% (HPLC), from Streptomyces rimosus

• Synonim(y): 4-Aminopyrrolo[2,3-d]pyrimidine-5-carbonitrile 7-(β-D-ribofuranoside), 7-Deaza-7-cyanoadenosine, NSC 63701, NSC 99843, Neuro 000027, Unamycin B, Vengicide
• Wzór empiryczny (zapis Hilla): C₁₂H₁₃N₅O₄
• Numer CAS: 606-58-6
• Masa cząsteczkowa: 291.26
• NACRES: NA.77
• PubChem Substance ID: 329826772
• UNSPSC Code: 12352200
• MDL number: MFCD00866513
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• biological source: Streptomyces rimosus
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: soluble 0.90-1.10 mg/mL, clear, colorless, H₂O: moderately soluble, aqueous acid: moderately soluble, ethanol: moderately soluble, methanol: moderately soluble
• antibiotic activity spectrum: fungi
• mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Nc1ncnc2n(cc(C#N)c12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
• InChI key: XOKJUSAYZUAMGJ-WOUKDFQISA-N

Opis

Biochem/physiol Actions

Toyocamycin is a nucleoside- type antibiotic analogue of adenosine, isolated from Streptomyces species. Toyocamycin is an anti-tumor antibiotic with various target activities. Toyocamycin is a potent inhibitor of RNA self-cleavage in mammalian cells. It also inhibits phosphatidylinositol kinase, a cell proliferation regulator. Toyocamycin was also found to inhibit Auxin signaling. Auxins are plant hormones with a crucial role in plant development regulation, and Toyocamycin was found to specifically inhibit auxin-responsive gene expression.

Toyocamycin is a nucleoside-type antibiotic analogue of adenosine, isolated from Streptomyces species. Toyocamycin is an anti-tumor antibiotic with various target inhibitory activities.

Studies have implicated that toyocamycin blocks the replication of fowl plague virus.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Toyocamycin is soluble in DMSO at 0.90 - 1.10 mg/ml and yields a clear, colorless solution. It is also soluble in acidic solutions and is moderately soluble in water, methanol and ethanol. Solutions prepared in DMSO can be diluted 10-fold in water.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable