U103

U-69593

selective κ opioid receptor agonist, solid

• Synonim(y): (+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide, U69593
• Wzór empiryczny (zapis Hilla): C₂₂H₃₂N₂O₂
• Numer CAS: 96744-75-1
• Masa cząsteczkowa: 356.50
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278769
• NACRES: NA.77
• MDL number: MFCD05664586
• Form: solid

Właściwości

• Nazwa produktu: U-69593, solid
• form: solid
• Quality Segment: 100
• optical activity: [α]/D +7.8°, c = 0.825 in methanol(lit.)
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL, 0.1 M HCl: >40 mg/mL, ethanol: >40 mg/mL, 0.1 M NaOH: insoluble, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccccc4
• InChI: 1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1
• InChI key: PGZRDDYTKFZSFR-ONTIZHBOSA-N
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988) ; mouse ... Oprk1(18387) ; rat ... Oprd1(24613), Oprk1(29335), Oprm1(25601)

Opis

Biochem/physiol Actions

U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

U-69593 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (10 mg/ml), 0.1 M HCl (>40 mg/ml), and ethanol (>40 mg/ml). However, it is insoluble in 0.1 M NaOH and water.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)