- A two-photon fluorescent probe for amyloid-β plaques in living mice.
A two-photon fluorescent probe for amyloid-β plaques in living mice.
Chemical communications (Cambridge, England) (2013-01-09)
Cheol Ho Heo, Kyung Ho Kim, Hyung Joong Kim, Sung Hoon Baik, Hyundong Song, Yong Soo Kim, Jeewoo Lee, Inhee Mook-jung, Hwan Myung Kim
PMID23295364
ABSTRAKT
We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.
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Naphthalene, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland