4,5-Di-O-Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation.

4,5-Di-O-Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation.

Phytotherapy research : PTR (2017-08-07)

Yiseul Kim, Jung Tae Kim, Joonwoo Park, Hee Jin Son, Eun-Young Kim, Young Joo Lee, Mee-Ra Rhyu

ABSTRAKT

Ligularia fischeri (Ledeb.) Turcz., a perennial plant native to northeastern Asia, has long been used as folk remedies for the alleviation of inflammatory symptoms. We investigated whether the extract of L. fischeri (LFEx) and caffeoylquinic acid (CQA) derivatives, the pharmacologically active ingredients identified from L. fischeri, regulate inflammation via a transient receptor potential vanilloid 1 (TRPV1)-mediated pathway. Changes in intracellular Ca

MATERIAŁY

Numer produktu

Marka

Opis produktu

C191

Sigma-Aldrich

Capsazepine, ≥98% (HPLC), solid

SMB00224

Sigma-Aldrich

3,4-Di-O-caffeoylquinic acid, ≥90% (LC/MS-ELSD)