L-Lysine-¹³C₆ hydrochloride

Name: <SC>L</SC>-Lysine-<SUP>13</SUP>C<SUB>6</SUB> hydrochloride
Brand: ALDRICH

99 atom % ¹³C, 95% (CP)

Synonym(s):

SILAC Amino Acid, (S)-2,6-Diaminocaproic acid-¹³C₆, ¹³C Labeled Lys, ¹³C Labeled lysine

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About This Item

Linear Formula:

H₂N(¹³CH₂)₄¹³CH(NH₂)¹³CO₂H · HCl

CAS Number:

1228077-86-8

Molecular Weight:

188.60

MDL number:

MFCD00144646

UNSPSC Code:

12352209

PubChem Substance ID:

24883268

NACRES:

NA.12

Key Documents

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isotopic purity

99 atom % ¹³C

Quality Level

200

Assay

95% (CP)

form

solid

optical activity

[α]25/D +20.7°, c = 2 in 5 M HCl

technique(s)

protein expression: suitable

mp

263-264 °C (dec.) (lit.)

mass shift

M+6

storage temp.

room temp

SMILES string

Cl.N[13CH2][13CH2][13CH2][13CH2][13C@H](N)[13C](O)=O

InChI

1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1;

InChI key

BVHLGVCQOALMSV-BOBMYJBMSA-N

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Chemistry & Biochemicals

Stable Isotopes

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Show Differences

1 of 4

This Item	616192	609021	608041
Sigma-Aldrich 643459 L-Lysine-¹³C₆ hydrochloride	Sigma-Aldrich 616192 L-Lysine-4,4,5,5-d₄ hydrochloride	Sigma-Aldrich 609021 L-Lysine-¹⁵N₂ hydrochloride	Sigma-Aldrich 608041 L-Lysine-¹³C₆,¹⁵N₂ hydrochloride
technique(s) protein expression: suitable	technique(s) protein expression: suitable	technique(s) bio NMR: suitable, protein expression: suitable	technique(s) bio NMR: suitable, protein expression: suitable
assay 95% (CP)	assay 98% (CP)	assay 98% (CP)	assay 95% (CP)
isotopic purity 99 atom % ¹³C	isotopic purity 98 atom % D	isotopic purity 98 atom % ¹⁵N	isotopic purity 99 atom % ¹³C, 99 atom % ¹⁵N
mass shift M+6	mass shift M+4	mass shift M+2	mass shift M+8
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form solid	form solid	form solid	form solid

Application

Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages. Identification of viral proteins from coronavirus infectious bronchitis-infected cells has been achieved with Stable Isotope labeling in conjunction with LC-MS/MS.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

related product

Product No.

Description

Pricing

D9443

Dulbecco′s Modified Eagle′s Medium - low glucose, liquid, sterile-filtered, suitable for cell culture, designed for isotope labeling in cell culture applications

R1780

RPMI-1640 Medium, With L-glutamine and sodium bicarbonate. Without arginine, leucine, lysine, and phenol red, liquid, sterile-filtered, suitable for cell culture, designed for isotope labeling for cell culture applications

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Gino L Turra et al.

Microbiology spectrum, 9(2), e0080921-e0080921 (2021-09-30)

Import and oxidative folding of proteins in the mitochondrial intermembrane space differ among eukaryotic lineages. While opisthokonts such as yeast rely on the receptor and oxidoreductase Mia40 in combination with the Mia40:cytochrome c oxidoreductase Erv, kinetoplastid parasites and other Excavata/Discoba

Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals changes in the cytoplasmic, nuclear, and nucleolar proteomes in Vero cells infected with the coronavirus infectious bronchitis virus.

Edward Emmott et al.

Molecular & cellular proteomics : MCP, 9(9), 1920-1936 (2010-05-15)

Virus-host interactions involve complex interplay between viral and host factors, rendering them an ideal target for proteomic analysis. Here we detail a high throughput quantitative proteomics analysis of Vero cells infected with the coronavirus infectious bronchitis virus (IBV), a positive

Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophage.

Stephanie D Kraft-Terry et al.

Journal of proteome research, 10(6), 2852-2862 (2011-04-20)

Dynamic interactions between human immunodeficiency virus-1 (HIV-1) and the macrophage govern the tempo of viral dissemination and replication in its human host. HIV-1 affects macrophage phenotype, and the macrophage, in turn, can modulate the viral life cycle. While these processes

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L-Lysine-13C6 hydrochloride

99 atom % 13C, 95% (CP)