S106

SR-95531

Name: SR-95531
Brand: SIGMA
Price: 2030 SEK

≥98% (HPLC), GABAA receptor antagonist , powder

Synonym(s):

2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide, Gabazine

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10 MG

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50 MG

7 530,00 kr

2 030,00 kr

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₈BrN₃O₃

CAS Number:

104104-50-9

Molecular Weight:

368.23

MDL number:

MFCD00055135

UNSPSC Code:

12352200

PubChem Substance ID:

24278819

NACRES:

NA.77

Key Documents

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Product Name

SR-95531, ≥98% (HPLC), powder

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white

solubility

H₂O: >10 mg/mL

SMILES string

[Br-].COc1ccc(cc1)-c2ccc(N)[n+](CCCC(O)=O)n2

InChI

1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChI key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
rat ... Gabra2(29706)

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This Item	SML0607	SML0917	PZ0285
Sigma-Aldrich S106 SR-95531	Sigma-Aldrich SML0607 Ceranib-2	Sigma-Aldrich SML0917 BMS-986122	Sigma-Aldrich PZ0285 PD168393
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: >10 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 25 mg/mL, clear
color white	color white to beige	color white to beige	color white to beige
Gene Information human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562) rat ... Gabra2(29706)	Gene Information -	Gene Information -	Gene Information -

Biochem/physiol Actions

SR-95531 is a specific GABA_A receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000222074

0000158055

0000158056

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Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.

Ian Duguid et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11132-11143 (2012-08-10)

Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which

Neprilysin Controls the Synaptic Activity of Neuropeptides in the Intercalated Cells of the Amygdala.

G C Gregoriou et al.

Molecular pharmacology, 98(4), 454-461 (2020-07-02)

Endogenous opioid peptides in the amygdala regulate many of our behaviors and emotional responses. In particular, the endogenous opioid enkephalin plays a significant role in regulating amygdala activity, but its action is strongly limited by peptidases, which degrade enkephalin into

Prolonged deficits in parvalbumin neuron stimulation-evoked network activity despite recovery of dendritic structure and excitability in the somatosensory cortex following global ischemia in mice.

Yicheng Xie et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 14890-14900 (2014-11-08)

Relatively few studies have examined plasticity of inhibitory neuronal networks following stroke in vivo, primarily due to the inability to selectively monitor inhibition. We assessed the structure of parvalbumin (PV) interneurons during a 5 min period of global ischemia and

Chromatic coding from cone-type unselective circuits in the mouse retina.

Le Chang et al.

Neuron, 77(3), 559-571 (2013-02-12)

Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis

Na+/K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cells.

Marvin R Diaz et al.

PloS one, 8(1), e55673-e55673 (2013-02-06)

Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in CGNs (CGN-I(tonic))

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SR-95531