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GABRA1

gamma-aminobutyric acid (GABA) A receptor, alpha 1

Synonimy:
ECA4, EJM, EJM5
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(2554) Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14394) gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
  • Rat(29705) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • domestic guinea pig(100721626) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • cow(780973) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • dog(489143) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • naked mole-rat(101719179) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • Zebrafish(768183) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • sheep(101117759) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • chicken(374214) gamma-aminobutyric acid (GABA) A receptor, alpha 1
  • domestic cat(100286792) gamma-aminobutyric acid (GABA) A receptor, alpha 1

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numer produktu
Opis
Gatunek
Gaboxadol hydrochloride, solid, ≥98% (HPLC),
Gatunek
human
Piperidine-4-sulfonic acid, ,
Gatunek
human
Isoguvacine hydrochloride, solid,
Gatunek
human
Muscimol hydrobromide, ≥98% (HPLC), solid,
Gatunek
human
Oxazepam, ,
Gatunek
human

Small Molecule - Allosteric Modulator

Numer produktu
Opis
Gatunek
Zolpidem solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Gatunek
human
Zaleplon solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Gatunek
human
Zolpidem for system suitability, CRS, European Pharmacopoeia (EP) Reference Standard,
Gatunek
human
Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder,
Gatunek
human
3α,21-Dihydroxy-5α-pregnan-20-one, ≥95%,
Gatunek
human

Small Molecule - Antagonist

Numer produktu
Opis
Gatunek
Norfloxacin, analytical standard, ≥98% (TLC),
Gatunek
rat, human
Ciprofloxacin, ≥98% (HPLC),
Gatunek
rat, human
Ofloxacin, fluoroquinolone antibiotic,
Gatunek
rat, human
Etiocholan-3α-ol-17-one, ,
Gatunek
human, rat
Ro 15-4513, solid,
Gatunek
rat, human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-GABA antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
drosophila, rat, wide range
Zastosowanie
dot blot
immunohistochemistry
Anti-GABRA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
western blot
Anti-GABA A Receptor α1 chain Antibody, NT, clone BD24, clone BD24, Chemicon®, from mouse,
Reaktywność gatunkowa
avian, bovine, human, pig
Zastosowanie
immunohistochemistry
immunoprecipitation (IP)

western blot
Przeciwciało przeciwko receptorowi GABA A β2/3, clone 62-3G1, Upstate®, from mouse,
Reaktywność gatunkowa
bovine, human, rat
Zastosowanie
immunohistochemistry
immunoprecipitation (IP)

western blot
Monoclonal Anti-GABRA1 antibody produced in mouse, clone S96-55, 1 mg/mL, purified immunoglobulin,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunocytochemistry
western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
2-Isopropylphenol, ≥98%, FG,
Gatunek
human
2-Isopropylphenol, 98%,
Gatunek
human
2,6-Xylenol, ≥99%, FG,
Gatunek
human
1,3-Diisopropylbenzene, 96%,
Gatunek
human
2,6-Dimethylphenol, ≥99.5%,
Gatunek
human

Small Molecule - Ligand

Numer produktu
Opis
Gatunek
Etomidate, >98% (HPLC), powder,
Gatunek
human
Flumazenil, >99% (HPLC), solid,
Gatunek
rat, human
Carbamazepine, powder,
Gatunek
rat, human

Small Molecule - Mixed Agonist/Antagonist

Numer produktu
Opis
Gatunek
2,6-Dimethoxyphenol, natural, ≥96%,
Gatunek
human
2-Hydroxy-3-isopropylbenzoic acid, 98%,
Gatunek
human
2,6-Dimethoxyphenol, 99%,
Gatunek
human
Phenol, ≥99%,
Gatunek
human
2-Cyclopentylphenol, technical grade, 95%,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human GABRA1,
Gatunek
human
MISSION® esiRNA, targeting mouse Gabra1,
Gatunek
mouse