NCSTUD002
MISSION® Synthetic microRNA Inhibitor
cel-miR-243-3p, Negative Control 2, Sequence from Caenorhabditis elegans with no homology to human and mouse gene sequences
Synonym(s):
Synthetic Tough Decoy, sTuD
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About This Item
UNSPSC Code:
41105324
NACRES:
NA.51
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product line
MISSION®
form
solid
mature sequence
CGGUACGAUCGCGGCGGGAUAUC
Sanger mature/minor accession no.
Sanger microRNA accession no.
storage temp.
−20°C
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1 of 3
This Item | MSTUD0114 | MSTUD0102 |
|---|---|---|
| Sanger mature/minor accession no. | Sanger mature/minor accession no. | Sanger mature/minor accession no. |
| mature sequence CGGUACGAUCGCGGCGGGAUAUC | mature sequence CCCAGUGUUCAGACUACCUGUUC | mature sequence UGGCUCAGUUCAGCAGGAACAG |
| product line MISSION® | product line MISSION® | product line MISSION® |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Sanger microRNA accession no. | Sanger microRNA accession no. - | Sanger microRNA accession no. - |
| form solid | form solid | form solid |
General description
Individual synthetic microRNA inhibitors were designed using a proprietary algorithm, which is based on the work of Haraguchi, T, et al. and in collaboration with Dr. Hideo Iba, University of Tokyo.† This algorithm utilizes the tough decoy (TuD) design. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation.
The MISSION synthetic miRNA Inhibitors are small, double-stranded RNA molecules designed to inhibit a specific mature miRNA. The miRNA inhibitors were designed using the mature miRNA sequence information from miRBase and are 2′-O-methylated RNA duplexes with a miRNA binding site on each strand. Optimal miRNA inhibition is provided after transfection due to the robust secondary structure of the inhibitor.
The MISSION synthetic miRNA Inhibitors are small, double-stranded RNA molecules designed to inhibit a specific mature miRNA. The miRNA inhibitors were designed using the mature miRNA sequence information from miRBase and are 2′-O-methylated RNA duplexes with a miRNA binding site on each strand. Optimal miRNA inhibition is provided after transfection due to the robust secondary structure of the inhibitor.
- Long lasting inhibition at very low dosage
- Excellent resistance to cellular nucleases
- Custom synthesis available for a variety of species
Other Notes
Based on miRBase V19
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
STOT RE 2 Inhalation
Target Organs
Respiratory Tract
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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