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CDK2

cyclin-dependent kinase 2

Synonyms:
p33(CDK2)
Species:
UniProtKB ID:
Gene ID:
  • Human(1017) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(12566) cyclin-dependent kinase 2
  • Rat(362817) cyclin dependent kinase 2
  • domestic guinea pig(100714324) cyclin-dependent kinase 2
  • Zebrafish(406715) cyclin-dependent kinase 2
  • chicken(100529062) cyclin-dependent kinase 2
  • naked mole-rat(101725353) cyclin-dependent kinase 2
  • dog(606931) cyclin-dependent kinase 2
  • domestic cat(101093368) cyclin-dependent kinase 2
  • sheep(100216433) cyclin-dependent kinase 2
  • Domestic Rabbit(100134865) cyclin-dependent kinase 2
  • cow(519217) cyclin-dependent kinase 2
  • Goat(100860751) cyclin-dependent kinase 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CDK2 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, goat, human, mouse, rabbit, rat, sheep
Application
immunohistochemistry
western blot
Anti-CDK2 (Ab-160) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-phospho-CDK2 (pThr160) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-phospho-CDK1/CDC2 (pThr14) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-phospho-CDK2 (pThr160) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Piceatannol, powder,
Species
human
Tyrphostin 23, ≥98%,
Species
human
NU2058, >98% (HPLC),
Species
human
Tyrphostin 51, ≥98%,
Species
human
6-O-Methylguanine, 97%,
Species
human

Proteins

Product Number
Description
Species
CDK2/CyclinE1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CDK2/Cyclin A2, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
CDK2/CyclinA1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cdk2,
Species
mouse
MISSION® esiRNA, targeting human CDK2,
Species
human