MilliporeSigma

DRD4

dopamine receptor D4

Synonyms:
D4DR
Species:
UniProtKB ID:
Gene ID:
  • Human(1815) Summary: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
  • Mouse(13491) dopamine receptor D4
  • Rat(25432) dopamine receptor D4
  • naked mole-rat(101708437) dopamine receptor D4
  • dog(448805) dopamine receptor D4
  • domestic guinea pig(100733356) dopamine receptor D4
  • dog(607223) dopamine receptor D4
  • chicken(423016) dopamine receptor D4

Custom & Knockdown Gene Products

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Small Molecule - Agonist

Product Number
Description
Species
PD 168,077 maleate salt, powder,
Species
human
Ropinirole hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Apomorphine hydrochloride hemihydrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
Ropinirole Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Ropinirole for peak identification 2, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
U-101958 maleate salt, solid,
Species
human
L-745,870 hydrochloride, ,
Species
human
L-741,626, ≥98% (HPLC),
Species
human
Droperidol, British Pharmacopoeia (BP) Reference Standard,
Species
human
Chlorpromazine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Drd4 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-DRD4 Antibody, clone 2B9, clone 2B9, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot
Anti-Dopamine D4 Receptor Antibody, extracellular domain, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
Anti-Dopamine D₄ Receptor Rabbit pAb, lyophilized, Calbiochem®,
Species Reactivity
human, rat
Application

Small Molecule - Inhibitor

Product Number
Description
Species
GBR 12909 dihydrochloride, solid, ≥98% (HPLC),
Species
human
Amoxapine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Amoxapine, 1.0 mg/mL in methanol, certified reference material, Cerilliant®,
Species
human
Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Bupropion hydrochloride, ≥98% (HPLC), solid,
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
3-Methoxytyramine hydrochloride, ≥95.5%, crystalline,
Species
human
3-Hydroxy-4-methoxyphenethylamine hydrochloride, ,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
BP897, >98% (HPLC), solid,
Species
human, rat
Haloperidol, powder,
Species
human, rat
Clozapine, ,
Species
human, rat

Small Molecule - Precursor

Product Number
Description
Species
3,4-Dihydroxy-DL-phenylalanine, ,
Species
mouse, human, rat
3,4-Dihydroxy-L-phenylalanine, ≥98% (TLC),
Species
mouse, human, rat

Proteins

Product Number
Description
Species
Dopamine D4 Receptor, control peptide for AB1789/AB1789P, ,
Species
rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Drd4,
Species
mouse