MilliporeSigma

PRKCA

protein kinase C, alpha

Synonyms:
AAG6, PKC-alpha, PKCA, PRKACA
Species:
UniProtKB ID:
Gene ID:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

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Small Molecule - Activator

Product Number
Description
Species
PKC Lipid Activator, ,
Species
human

Small Molecule - Agonist

Product Number
Description
Species
Oleic acid, ≥99% (GC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-Phospho-PKC (pan) (zeta)-T410 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-PKC alpha Antibody, clone 1G10S8, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Phospho-PKCalpha-S319 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-Phospho-PKCalpha-S226 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
1-Oleoyl-2-acetyl-sn-glycerol, ≥97% (TLC), oil,
Species
human
D-Sphingosine, synthetic,
Species
rat
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
Species
rat, human
K-252a, from Nonomuraea longicatena, ≥98% (HPLC),
Species
rat, human
(S)-(+)-Camptothecin, ≥90% (HPLC), powder,
Species
rat, mouse, human

Proteins

Product Number
Description
Species
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Species
human
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Species
human
PKC-α, active, GST tagged from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Prkca,
Species
mouse
MISSION® esiRNA, targeting human PRKCA,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
Species
human
PKC Substrate Cocktail, ,
Species
human