STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms:
APRF, HIES
Species:
Human STAT3 (6774), Mouse Stat3 (20848), Rat Stat3 (25125), naked mole-rat Stat3 (101721899), domestic guinea pig Stat3 (100717084), chicken STAT3 (420027), Zebrafish stat3 (30767), sheep STAT3 (100294659), domestic cat STAT3 (101095698), cow STAT3 (508541) ...More
UniProtKB ID:
Gene ID:
- Human(6774) Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(20848) signal transducer and activator of transcription 3
- Rat(25125) signal transducer and activator of transcription 3 (acute-phase response factor)
- naked mole-rat(101721899) signal transducer and activator of transcription 3 (acute-phase response factor)
- domestic guinea pig(100717084) signal transducer and activator of transcription 3 (acute-phase response factor)
- chicken(420027) signal transducer and activator of transcription 3 (acute-phase response factor)
- Zebrafish(30767) signal transduction and activation of transcription 3
- sheep(100294659) signal transducer and activator of transcription 3 (acute-phase response factor)
- domestic cat(101095698) signal transducer and activator of transcription 3 (acute-phase response factor)
- cow(508541) signal transducer and activator of transcription 3 (acute-phase response factor)
- Horse(100052852) signal transducer and activator of transcription 3 (acute-phase response factor)
- Domestic Rabbit(100348778) signal transducer and activator of transcription 3 (acute-phase response factor)
- dog(490967) signal transducer and activator of transcription 3 (acute-phase response factor)
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ELISA
Product Number
Description
Species
Phosphotyrosine STAT3 / Signal Transducer and Activator of Transcription 3 ELISA Kit, ,
Species
human
Phospho-Stat3 (pTyr705) and pan-Stat3 ELISA Kit, for detection of phospho-stat3 (pTyr705) and pan-stat3 in human, mouse or rat cell and tissue lysates,
Species
mouse, rat, human
Phospho-Stat3 (pTyr705) ELISA Kit, for detection of phospho-stat3 (pTyr705) in human, mouse or rat cell and tissue lysates,
Species
mouse, rat, human
Cell-Based ELISA for detecting phospho-STAT3 (pTyr705) in cultured cell lines, 96 assays,
Species
mouse, rat, human
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-STAT3 antibody produced in mouse, clone 4D6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
proximity ligation assay
western blot
immunofluorescence
proximity ligation assay
western blot
Anti-STAT3 (Ab-727) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-phospho-STAT3 (pSer727) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-STAT3 (pSer727) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-STAT3 antibody produced in mouse, clone 1D11-2A11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot