Skip to Content
MilliporeSigma

U3385

UA62784

≥98% (HPLC)

Synonym(s):

4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one

Slide 1 of 1
Sign In to View Organizational & Contract Pricing.

Select a Size

5 MG

$153.00

$153.00

0 left in stock
Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C23H15NO3
CAS Number:
313367-92-9
Molecular Weight:
353.37
NACRES:
NA.77
PubChem Substance ID:
329827627
UNSPSC Code:
12352202
MDL number:
MFCD00489199

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

UA62784, ≥98% (HPLC)

InChI

1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3

SMILES string

COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34

InChI key

SVICLWPFAQYZLX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >2 mg/mL

storage temp.

2-8°C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML1827SML2225SML1464
UA62784 ≥98% (HPLC)

Sigma-Aldrich

U3385

UA62784

CCF642 ≥98% (HPLC)

Sigma-Aldrich

SML1827

CCF642

RO5263397 ≥98% (HPLC)

Sigma-Aldrich

SML2225

RO5263397

SMBA1 ≥98% (HPLC)

Sigma-Aldrich

SML1464

SMBA1

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >2 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

yellow

color

yellow to orange

color

white to beige

color

white to beige

Biochem/physiol Actions

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor[1].
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Preparation Note

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
059K4633V
059K46331
059K4633

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sergey Tcherniuk et al.
Chemistry & biology, 18(5), 631-641 (2011-05-26)
A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. We found that UA62784 inhibits microtubule polymerization in vitro. UA62784 interacts with tubulin dimers ten times more potently than colchicine, vinblastine, or nocodazole. Competition experiments revealed that UA62784
Julia Würtemberger et al.
PloS one, 15(9), e0238572-e0238572 (2020-09-09)
Functional genomic screening of KRAS-driven mouse sarcomas was previously employed to identify proliferation-relevant genes. Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2), and CAMP Responsive Element Binding Protein 3 Like 2 (Creb3l2). This

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service