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344827

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose

2F-Peracetyl-Fucose is a cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic.

Sinónimos:

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose, (3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate

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Talla/SKUDisponibilidadPrecio
10 mg
Comprobar disponibilidad del carrito
$371.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C12H17FO7
Peso molecular:
292.26
NACRES:
NA.77
UNSPSC Code:
12352111
eCl@ss:
32150917
Assay:
≥98% (NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light

$371.00


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Quality Segment

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Fucosyltransferase
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rillahan, C., et al. 2012.. Nat. Chem. Bio.8, 661.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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form

solid

form

solid

form

solid

form

solid

assay

≥98% (NMR)

assay

≥98% (NMR)

assay

≥95% (1H-NMR)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL


Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 1

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable



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