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B150

BQ-123

≥99%, sodium salt, lyophilized powder

Sinónimos:

BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

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Talla/SKUDisponibilidadPrecio
1 mg
13 left in stock
$532.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C31H41N6O7 Na
Número CAS:
Peso molecular:
632.68
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Assay:
≥99%
Form:
lyophilized powder

$532.00


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Quality Segment

assay

≥99%

form

lyophilized powder

storage temp.

−20°C

SMILES string

[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C

InChI

1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

InChI key

VYCMAAOURFJIHD-PJNXIOHISA-N

Gene Information

Application

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Biochem/physiol Actions

BQ-123 is an endothelin(Et) receptor antagonist and is exquisite for endothelin A (ETA) receptor. It is a cyclic pentapeptide.
Selective ETA endothelin receptor antagonist.

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Este artículo
B157E3651E9780
description

≥99%, sodium salt, lyophilized powder

description

≥95%, solid

description

affinity isolated antibody, lyophilized powder

description

affinity isolated antibody, buffered aqueous solution

assay

≥99%

assay

≥95%

assay

-

assay

-

form

lyophilized powder

form

solid

form

lyophilized powder

form

buffered aqueous solution

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

Gene Information

human ... EDNRA(1909), EDNRB(1910)
rat ... Ednra(24326), Ednrb(50672)

Gene Information

human ... EDNRB(1910)
mouse ... EDNRB(13618)
rat ... EDNRB(50672)

Gene Information

human ... EDNRA(1909)
rat ... Ednra(24326)

Gene Information

human ... EDNRA(1909)
mouse ... Ednra(13617)
rat ... Ednra(24326)


Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, type N95 (US)



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Questions

1–4 of 4 Questions  
  1. How should Product B150, BQ-123, be dissolved?

    1 answer
    1. This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.

      Helpful?

  2. What is the solution stability for Product B150, BQ-123?

    1 answer
    1. We do not perform any solution stability studies on Product B150, BQ-123. The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned.  Cardillo, C. et al., Hypertension, 33, 753-758 (1999).  The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment.  Bonvollet, S. et al., A.J.P. - Heart, 266 (4), H1327-H1331 (1994).

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. Is Product B150 the free acid form of BQ-123, or is it a salt?

    1 answer
    1. Product No. B150 is BQ123 sodium salt.

      Helpful?

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