B8312

BNTX maleate salt hydrate

≥98% (HPLC)

• Sinónimos: 7(E)-Benzylidenenaltrexone maleate salt hydrate, BNTX-7 maleate salt hydrate, Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-7-(phenylmethylene)-,(5a,7E)- maleate salt hydrate
• Fórmula empírica (notación de Hill): C₃₁H₃₁NO₈ · xH₂O
• Peso molecular: 545.58 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329773306
• UNSPSC Code: 12352200
• MDL number: MFCD12912399
• eCl@ss: 32160703
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: yellow
• solubility: DMSO: >20 mg/mL
• storage temp.: −20°C
• SMILES string: O.OC(=O)\C=C/C(O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)\C(C[C@@]35O)=C\c6ccccc6)CC7CC7
• InChI: 1S/C27H27NO4.C4H4O4.H2O/c29-20-9-8-18-13-21-27(31)14-19(12-16-4-2-1-3-5-16)23(30)25-26(27,22(18)24(20)32-25)10-11-28(21)15-17-6-7-17;5-3(6)1-2-4(7)8;/h1-5,8-9,12,17,21,25,29,31H,6-7,10-11,13-15H2;1-2H,(H,5,6)(H,7,8);1H2/b19-12+;2-1-;/t21-,25+,26+,27-;;/m1../s1
• InChI key: AGUNLJBLOJAUKM-ZKJXOIBSSA-N

Descripción

Application

BNTX, a selective nonpeptide σ1 opioid receptor (DOR1) antagonist, is used in σ opioid receptor research to help differentiate and characterized the function and role of the σ1 opioid receptor versus other σ opioid receptor subtypes. BNTX was used to help define the role of σ1 opioid receptors in neurological processes such as anxiety. It was used to help define the role of σ opioid receptors in myocardial infarct development and size.

Biochem/physiol Actions

BNTX is a selective d1 non peptide opioid receptor antagonist.

BNTX is a selective nonpeptide δ₁ opioid receptor antagonist. It antagonizes the effect of D-Pen^2,5-enkephalin (a δ₁ agonist 4-6 fold, but did not affect the activity of δ₂ or μ agonists.<<<107>>> BNTX is used to discriminate among opioid receptor subtypes in effects such as alcohol and drug dependence. It binds 100× more tightly to δ₁ than to δ₂ receptors. In the tail-flick assay, antinocieceptive ED50 = 646.4 pmol/mouse.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de advertencia: Warning
• Códigos de peligro: H319,H400
• Indicaciones de precaución: P273 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2
• Clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves