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MilliporeSigma

L7877

Lactulose

≥95% (HPLC)

Sinónimos:

4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C12H22O11
Número CAS:
Peso molecular:
342.30
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
225-027-7
Beilstein/REAXYS Number:
93773
MDL number:
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Nombre del producto

Lactulose, ≥95% (HPLC)

InChI key

JCQLYHFGKNRPGE-WJONTELPSA-N

InChI

1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12+/m1/s1

SMILES string

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

biological source

synthetic

assay

≥95% (HPLC)

form

powder

optical activity

[α]20/D -52.0 to -48.0 °, c = 4% (w/v) in water

color

white to off-white

mp

169  °C ((336 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

Quality Level

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Biochem/physiol Actions

Lactulose is a synthetic disaccharide derived from galactose and fructose. It is not absorbed in the gut and is frequently used in the treatment of constipation and hepatic encephalopathy. Studies have reported that lactulose administration may cause an increase in fecal nitrogen. It is also known to function as a prebiotic. Lactulose measurements can be used to detect gastrointestinal dysfunctions.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Huifang Yin et al.
Carbohydrate research, 465, 58-65 (2018-06-27)
Oligosaccharides derived from lactulose (β-D-Galp-(1 → 4)-D-Fru) are drawing more and more attention nowadays because of their strong resistance to gut digestion, and the interest to discover novel prebiotics. Compared to galactooligosaccharides, currently known structures of lactulose oligosaccharides are very limited. In
Tara Raftery et al.
United European gastroenterology journal, 3(3), 294-302 (2015-07-03)
Vitamin D (vitD) supplementation may prolong remission in Crohn's disease (CD); however, the clinical efficacy and mechanisms are unclear. To determine changes in intestinal permeability (IP), antimicrobial peptide (AMP) concentrations and disease markers in CD, in response to vitD supplementation.
Edwin R Price et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 164(2), 351-355 (2012-11-21)
Flying vertebrates have been hypothesized to have a high capacity for paracellular absorption of nutrients. This could be due to high permeability of the intestines to nutrient-sized molecules (i.e., in the size range of amino acids and glucose, MW 75-180
J Zhao et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(6), 794-802 (2014-03-20)
Small intestinal bacterial overgrowth (SIBO) may be a cause of irritable bowel syndrome (IBS); however, current investigations have important limitations. We aimed to identify clinically relevant diagnostic criteria for SIBO based on lactulose hydrogen breath test (LHBT) alone and combined
Kostan W Reisinger et al.
Journal of pediatric gastroenterology and nutrition, 59(6), 720-724 (2014-08-12)
The incidence of necrotizing enterocolitis (NEC) is higher in formula-fed babies than in breast-fed babies, which may be caused by breast-feeding-induced gut maturation. The effect of breast-feeding on gut maturation has been widely studied in animal models. This study aimed

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