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MilliporeSigma

NCSTUD002

MISSION® Synthetic microRNA Inhibitor

cel-miR-243-3p, Negative Control 2, Sequence from Caenorhabditis elegans with no homology to human and mouse gene sequences

Sinónimos:

Synthetic Tough Decoy, sTuD

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Acerca de este artículo

NACRES:
NA.51
UNSPSC Code:
41105324

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Nombre del producto

MISSION® Synthetic microRNA Inhibitor, cel-miR-243-3p, Negative Control 2, Sequence from Caenorhabditis elegans with no homology to human and mouse gene sequences

product line

MISSION®

form

solid

mature sequence

CGGUACGAUCGCGGCGGGAUAUC

Sanger mature/minor accession no.

Sanger microRNA accession no.

storage temp.

−20°C

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Este artículo
MSTUD0114MSTUD0102
Sanger mature/minor accession no.

MIMAT0000299

Sanger mature/minor accession no.

MIMAT0000229

Sanger mature/minor accession no.

MIMAT0000219

mature sequence

CGGUACGAUCGCGGCGGGAUAUC

mature sequence

CCCAGUGUUCAGACUACCUGUUC

mature sequence

UGGCUCAGUUCAGCAGGAACAG

product line

MISSION®

product line

MISSION®

product line

MISSION®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Sanger microRNA accession no.

MI0000319

Sanger microRNA accession no.

-

Sanger microRNA accession no.

-

form

solid

form

solid

form

solid

General description

Individual synthetic microRNA inhibitors were designed using a proprietary algorithm, which is based on the work of Haraguchi, T, et al. and in collaboration with Dr. Hideo Iba, University of Tokyo.† This algorithm utilizes the tough decoy (TuD) design. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation.

The MISSION synthetic miRNA Inhibitors are small, double-stranded RNA molecules designed to inhibit a specific mature miRNA. The miRNA inhibitors were designed using the mature miRNA sequence information from miRBase and are 2′-O-methylated RNA duplexes with a miRNA binding site on each strand. Optimal miRNA inhibition is provided after transfection due to the robust secondary structure of the inhibitor.

  • Long lasting inhibition at very low dosage
  • Excellent resistance to cellular nucleases
  • Custom synthesis available for a variety of species

Other Notes

Based on miRBase V19

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

STOT RE 2 Inhalation

target_organs

Respiratory Tract

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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