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O7389

Olprinone hydrochloride

Name: Olprinone hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Sinónimos:

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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Fórmula empírica (notación de Hill):

C₁₄H₁₀N₄O · HCl

Número CAS:

119615-63-3

Peso molecular:

286.72

NACRES:

NA.77

PubChem Substance ID:

24724566

UNSPSC Code:

41106305

MDL number:

MFCD01749474

Assay:

≥98% (HPLC)

Form:

solid

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assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL, H₂O: 6.8 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number

056K47151

056K4715

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Intermittent infusions of carperitide or inotoropes in out-patients with advanced heart failure.

Kiyoto Nishi et al.

Journal of cardiology, 59(3), 366-373 (2012-03-01)

The ambulatory treatment of advanced heart failure (HF) with intermittent infusions of inotropes or natriuretic peptide chosen immediately before each infusion has not been described. Between May 2005 and July 2009, we treated 11 patients presenting with advanced HF, who

[Effect of landiolol and combined use of landiolol and olprinone on hemodynamics in patients undergoing off-pump coronary artery bypass grafting].

Mayumi Tachikawa et al.

Masui. The Japanese journal of anesthesiology, 61(6), 566-573 (2012-07-04)

Beta blockers are frequently used to reduce cardiac oxygen demand in off-pump coronary artery bypass grafting (OPCAB). However, significant bradycardia or negative inotropic effects are seen on occasion. We hypothesized that combined use of landiolol (L), an ultra short-acting beta

Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.

Hirofumi Oishi et al.

American journal of physiology. Lung cellular and molecular physiology, 303(2), L130-L140 (2012-05-23)

Olprinone, a specific phosphodiesterase III inhibitor, and corforsin daropate, a direct adenylate cyclase activator, are now being used in critical conditions. We investigated whether their therapeutic use provides protection against septic acute lung injury (ALI) and mortality. Polymicrobial sepsis was

Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs.

Jing Zhou et al.

European journal of anaesthesiology, 28(7), 519-524 (2011-04-16)

Phosphodiesterase 3 (PDE3) inhibitors and sevoflurane are both known to have bronchodilator properties and the combination of these two agents may be synergistic. We tested this hypothesis in a model of airway hyperresponsiveness using ovalbumin-sensitised guinea pigs. Animals were randomised

Transient cardiac arrest in patient with left ventricular noncompaction (spongiform cardiomyopathy).

Shinya Yamazaki et al.

Anesthesia progress, 58(1), 22-25 (2011-03-18)

Left ventricular noncompaction (LVNC), also known as spongiform cardiomyopathy, is a severe disease that has not previously been discussed with respect to general anesthesia. We treated a child with LVNC who experienced cardiac arrest. Dental treatment under general anesthesia was

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Número de artículo de comercio global

SKU	GTIN
O7389-10MG	04061832899039
O7389-50MG	04061832899046

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