SML2267

GeA-69

≥98% (HPLC)

• Sinónimos: N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
• Fórmula empírica (notación de Hill): C₂₀H₁₆N₂O
• Número CAS: 2143475-98-1
• Peso molecular: 300.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: off-white to brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
• InChI key: LDPDVNYCIOHPGF-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.

Selective allosteric inhibitor of PARP14 macrodomain 2

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable