- Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.
Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.
Carbohydrate research (2014-12-17)
Akiharu Ueki, Keita Un, Yuka Mino, Mitsuru Yoshida, Shigeru Kawakami, Hiromune Ando, Hideharu Ishida, Fumiyoshi Yamashita, Mitsuru Hashida, Makoto Kiso
PMID25500195
RESUMEN
Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently taken up by cells expressing carbohydrate-binding receptors selectively. Glyco-coated liposomes are promising candidates for drug delivery vehicles.
MATERIALES
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Sigma-Aldrich
Hidróxido de sodio, puriss., meets analytical specification of Ph. Eur., BP, NF, E524, 98-100.5%, pellets
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Agua, for embryo transfer, sterile-filtered, BioXtra, suitable for mouse embryo cell culture
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Hidróxido de sodio, puriss. p.a., ACS reagent, reag. Ph. Eur., K ≤0.02%, ≥98%, pellets
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SyntheChol® NS0 Supplement, 500 ×, synthetic cholesterol, animal component-free, sterile-filtered, aqueous solution, suitable for cell culture