Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses, or any type of consumption or application to humans or animals.
92283
Polymyxin B solution
20 mg/mL in H2O
Synonym(s):
Aerosporin, Polymyxin B, Polymyxin B Sulfate
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| Size/SKU | Availability | Price |
|---|---|---|
10 mL | Available to ship onSeptember 23, 2026fromMILWAUKEE | $473.00 $354.75 |
125 mL | Estimated to ship onOctober 29, 2026fromSAINT LOUIS | $5,420.00 |
About This Item
$354.75
List Price$473.00Save 25%Web-Only Promotion
Available to ship onSeptember 23, 2026Details
biological source
Bacillus polymyxa (fermentation)
Quality Segment
form
liquid
optical activity
[α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
concentration
20 mg/mL in H2O
color
colorless to slightly yellow
solubility
H2O: soluble 20 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, fungi
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(O)O.N1CCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCO)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)C(NC(=O)C(NC(=O)C(NC=O)CCN)CCO)CCN
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
General description
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa.
Application
Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochem/physiol Actions
Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.
Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.
Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.
Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.
Packaging
10ml, 125ml
Preparation Note
This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.
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This Item | |||
|---|---|---|---|
| description 20 mg/mL in H2O | description 1 mg/mL in H2O, analytical standard | description Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases. | description European Pharmacopoeia (EP) Reference Standard |
| mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action - | mode of action - |
| antibiotic activity spectrum fungi, Gram-positive bacteria, Gram-negative bacteria | antibiotic activity spectrum fungi, Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level - |
| form liquid | form - | form solid | form - |
| solubility H2O: soluble 20 mg/mL | solubility - | solubility water: 25 mg/mL | solubility - |
| concentration 20 mg/mL in H2O | concentration 1 mg/mL in H2O | concentration - | concentration - |
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Storage Class
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves
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