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31375

Dexamethasone

tested according to Ph. Eur.

Synonym(s):

Dexamethasonum, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

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Size/SKUAvailabilityPrice
500 mg

Available to ship TODAYfromMILWAUKEE

$336.00
$252.00

About This Item

Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
Molecular Weight:
392.46
UNSPSC Code:
41116107
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
Assay:
99.6%
Form:
solid

$252.00

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Quality Segment

agency

tested according to Ph. Eur.

assay

99.6%

form

solid

mp

262-264 °C (lit.)

solubility

water: soluble 10mg/100 ml at 25 °C, acetone: very slightly soluble, alcohol: very slightly soluble, chloroform: slightly soluble, diethyl ether: very slightly soluble, dioxane: very slightly soluble, methanol: very slightly soluble

application(s)

research use (small molecule)

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Application

Dexamethasone has been used as a DMEM medium supplement utilized in osteogenesis. It has also been used as an alpha-MEM medium supplement to initiate adipogenic differentiation. Additionally, it has also been used to study apoptosis, cell signaling pathways and gene expression.

Biochem/physiol Actions

Dexamethasone is a glucocorticoid anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Additionally, dexamethasone inhibits the induction of nitric oxide synthase. It induces apoptosis by initiating the initial cleavage of DNA into high molecular weight fragments.
Glucocorticoid anti-inflammatory agent
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

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This Item
PHR152646165D8893
description

tested according to Ph. Eur.

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

VETRANAL®, analytical standard

description

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

form

solid

form

-

form

-

form

powder

assay

99.6%

assay

-

assay

-

assay

≥80% (HPLC)

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

200

solubility

dioxane: very slightly soluble, water: soluble 10mg/100 ml at 25 °C, chloroform: slightly soluble, diethyl ether: very slightly soluble, acetone: very slightly soluble, methanol: very slightly soluble, alcohol: very slightly soluble

solubility

chloroform: slightly soluble, acetone: sparingly soluble, dioxane: soluble, DMSO: soluble, ether: very slightly soluble, methanol: sparingly soluble, water: practically insoluble

solubility

-

solubility

ethanol: 1 mL/vial, clear

agency

tested according to Ph. Eur.

agency

traceable to Ph. Eur. D0700000, BP, USP, traceable to USP 1176007, EP

agency

-

agency

-

application(s)

research use (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

clinical

application(s)

-


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pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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