SYNPLE-P072
Reagent-cartridge CRBN-COOH-PEG2
Synple
別名:
Synple 2
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この商品について
製品SYNPLE-P072は現在お客様の国では販売されていません。 製品に関するお問い合わせはこちら（テクニカルサービス）
reaction suitability
reaction type: PROTAC formation
SMILES string
[s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C
InChI
1S/C28H38N4O7S/c1-17-24(40-16-30-17)19-7-5-18(6-8-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)9-11-39-12-10-23(35)36/h5-8,16,20-21,25,33H,9-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1
InChI key
HVPZHRHEHKZOOJ-TYBLODHISA-N
General description
Reagent-cartridge CRBN-COOH-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected amine to the carboxylic acid terminated linker through an amide coupling. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.
Scale: up to 0.1 mmol
Linker: PEG2
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: carboxylic acid
Compatible substrates: amine
Cartridge contents:
Learn more about protein degradation.
Explore all our Protein Degrader Building Blocks.
Features and Benefits of Synple Platform
Scale: up to 0.1 mmol
Linker: PEG2
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: carboxylic acid
Compatible substrates: amine
Cartridge contents:
- Supported carbodiimide and Oxyma Pure (coupling reagents)
- Supported carbonate (acid scavenger)
- SCX2 (for purification)
- Degrader building block linker reagent
- SYNPLE-P002 Reagent-cartridge CRBN-PEG2
- SYNPLE-P003 Reagent-cartridge CRBN-PEG3
- SYNPLE-P004 Reagent-cartridge CRBN-PEG4
- SYNPLE-P005 Reagent-cartridge CRBN-PEG5
- SYNPLE-P021 Reagent-cartridge VHL-PEG1
- SYNPLE-P022 Reagent-cartridge VHL-PEG2
- SYNPLE-P023 Reagent-cartridge VHL-PEG3
- SYNPLE-P024 Reagent-cartridge VHL-PEG4
- SYNPLE-P025 Reagent-cartridge VHL-PEG5
- SYNPLE-P073 Reagent-cartridge CRBN-COOH-PEG3
- SYNPLE-P074 Reagent-cartridge CRBN-COOH-PEG4
- SYNPLE-P082 Reagent-cartridge VHL-COOH-PEG2
- SYNPLE-P083 Reagent-cartridge VHL-COOH-PEG3
- SYNPLE-P084 Reagent-cartridge VHL-COOH-PEG4
Learn more about protein degradation.
Explore all our Protein Degrader Building Blocks.
Features and Benefits of Synple Platform
- Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
- Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
- Safety – all chemicals are contained in the system, minimizing the user’s exposure
- Set-up reaction in less than 5 minutes
- Small footprint
- Plug & Play system – simple installation
- Reaction temperatures from 25 °C – 80 °C
- Cartridges available for many different reactions
- Prefilled with all required reagents
- RFID chip containing optimized reaction protocol
Other Notes
Legal Information
Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
保管分類
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Deleterious substance
pdsc
SYNPLE-P072-1EA:
jan