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A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

Synonym(e):

N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

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Ihnen/SKUVerfügbarkeitPreis
1 g
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€ 73,50
5 g
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€ 292,00
10 g
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Über diesen Artikel

Empirische Formel (Hill-System):
C6H8ClN7O · HCl · xH2O
CAS-Nummer:
Molekulargewicht:
266.09 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

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Produktname

Amiloride hydrochloride hydrate, ≥98% (HPLC), powder

Quality Segment

assay

≥98% (HPLC)

form

powder

color

, White to Yellow and Faint Green to Green and Yellow-Green

mp

285-288 °C (dec.)

solubility

H2O: 50 mg/mL, hazy (Very Faint Yellow to Dark Yellow and Very Faint Green-Yellow to Dark Green-Yellow and Very Faint Brown-Yellow to Dark Brown-Yellow)

originator

Perrigo

storage temp.

room temp

SMILES string

O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2

InChI key

WDZJJRLYFQNCQL-UHFFFAOYSA-N

Application

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

Biochem/physiol Actions

Selective T-type Ca2+ and epithelial sodium channel blocker
Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

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Dieser Artikel
A4562B2417SML0460
assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

solid

form

powder

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

H2O: 50 mg/mL, hazy (Very Faint Yellow to Dark Yellow and Very Faint Green-Yellow to Dark Green-Yellow and Very Faint Brown-Yellow to Dark Brown-Yellow)

solubility

-

solubility

methanol: 10 mg/mL, DMSO: >20 mg/mL

solubility

H2O: 5 mg/mL (clear solution)

color

, White to Yellow and Faint Green to Green and Yellow-Green

color

-

color

yellow

color

white to beige

originator

Perrigo

originator

-

originator

-

originator

-


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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