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Nazwa produktu
MabSelect™ SuRe™, Cytiva 17-5438-02, pack of 200 mL
technique(s)
liquid chromatography (LC): suitable
matrix
highly cross-linked agarose
form
resin
crosslinking
cross-linked
packaging
pack of 200 mL
manufacturer/tradename
Cytiva 17-5438-02
storage condition
(20% Ethanol)
parameter
100-500 cm/hr flow rate
matrix active group
alkali-stabilized protein A-derived (E. coli)
avg. part. size
~85 μm
cleaning in place
3-13.7
working range
3-12
capacity
~35 mg binding capacity (human lgG / ml)
separation technique
affinity
storage temp.
2-8°C
Powiązane kategorie
1 of 4
Ta pozycja | GE17-5438-01 | GE17-5474-01 | GE17-5474-02 |
|---|---|---|---|
| matrix highly cross-linked agarose | matrix highly cross-linked agarose | matrix highly cross-linked agarose | matrix highly cross-linked agarose |
| capacity ≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time) | capacity ≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time) | capacity ~60 mg binding capacity | capacity ~60 mg binding capacity |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| manufacturer/tradename Cytiva 17-5438-02 | manufacturer/tradename Cytiva 17-5438-01 | manufacturer/tradename Cytiva 17-5474-01 | manufacturer/tradename Cytiva 17-5474-02 |
| storage condition (20% Ehtanol) | storage condition (20% Ehtanol) | storage condition (20% Ehtanol) | storage condition (20% Ehtanol) |
| packaging pack of 200 mL | packaging pack of 25 mL | packaging pack of 25 mL | packaging pack of 200 mL |
Analysis Note
Features and Benefits
- Novel, alkali-tolerant rProtein A ligand withstands rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH.
- Reduces the risk of product contamination and carryover
- Improves product quality and reduces overall costs
- Novel ligand design gives enhanced protease resistance resulting in lower ligand leakage
- Generic elution profile for different monoclonal antibodies enables platform approach to purification
- Used in the commercial manufacture of monoclonal antibodies
- High-flow agarose matrix allows the processing of large feed volumes
General description
MabSelect™ SuRe™ is a member of the MabSelect™ family of affinity chromatography media for the capture of monoclonal antibodies (MAbs) at process scale. MabSelect™ SuRe™ shares features and benefits of MabSelect™ such as a rigid, high-flow agarose matrix that ensures excellent pressure/flow properties, low non-specific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for optimal binding capacity. In addition, MabSelect™ SuRe™ features an alkali-tolerant rProtein A ligand. This ligand provides greater stability than conventional protein A-based media in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols. The enhanced alkali stability of MabSelect™ SuRe™ improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl.
The novel ligand construct of MabSelect™ SuRe™ has been proven to have an increased stability towards proteases. Therefore, the level of leakage of the MabSelect™ SuRe™ ligand during elution is low. MabSelect™ SuRe™ has been demonstrated to give generic elution conditions for different monoclonal antibodies, which is an advantage when designing generic purification platform processes. This feature is also correlated to the construction of the MabSelect™ SuRe™ ligand.
MabSelect™ SuRe™ is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect™ SuRe™ meets industrial demands with security of supply and comprehensive technical and regulatory support.
Legal Information
"MabSelect SuRe Ligand Restricted License" and "Cys-rProtein A Ligand Restricted License" are protected by the following patents and equivalent patents and patent applications in other countries: US 6,399,750 and EP 1123389. A free, non-transferable limited license to use this product for internal analytical purposes only accompanies the purchase of the product from a Cytiva company and its licensed distributors. Any other use will require a separate license from a Cytiva company.
Preparation Note
signalword
Warning
hcodes
Klasa składowania
3 - Flammable liquids
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