MTOX1002
BCRP Knockout Caco-2 Cells
Human male colorectal tissue, adenocarcinoma
Synonym(s):
C2BBe1 Cells BCRP (-/-/-/-)
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| Size/SKU | Availability | Price |
|---|---|---|
1 vial | Usually ships in 3 weeks. | $2,110.00 |
About This Item
Product Name
BCRP Knockout Caco-2 Cells, one vial
biological source
human male colorectal tissue (Source disease: adenocarcinoma)
Quality Segment
form
liquid
technique(s)
drug transporter assay: suitable, permeability assay: suitable
OMIM accession no.
application(s)
ADME/TOX
storage temp.
−196°C
Gene Information
human ... ABCG2(9429)
General description
Application
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
Features and Benefits
- A functional knockout of the BCRP gene eliminates the reliance on chemical inhibitors to determine if a compound is an BCRP substrate
- The vial format enables the BCRP knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
Legal Information
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| description one vial | description one vial | description one vial | description one vial |
| biological source human male colorectal tissue (Source disease: adenocarcinoma) | biological source human male colorectal tissue (Source disease: adenocarcinoma) | biological source human male colorectal tissue (Source disease: adenocarcinoma) | biological source human male colorectal tissue (Source disease: adenocarcinoma) |
| technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable | technique(s) drug transporter assay: suitable, permeability assay: suitable |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| OMIM accession no. | OMIM accession no. | OMIM accession no. | OMIM accession no. |
| Gene Information human ... ABCG2(9429) | Gene Information human ... ABCC2(1244), ABCG2(9429) | Gene Information human ... ABCB1(5243), ABCG2(9429) | Gene Information human ... ABCB1(5243), ABCC2(1244) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
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Kit Components Also Available Separately
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
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