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Structural Genomics Consortium

Target validation using SGC chemical probes

In your research, it is essential to ensure that your target is the right target. We have partnered with the Structural Genomics Consortium (SGC) to provide highly characterized, novel chemical probes for researching clinically relevant protein targets. These probes, developed and characterized by the SGC, meet strict criteria for potency, selectivity, and cell-permeability in order to be used as essential tools in preclinical target validation. Originally focusing on proteins involved in epigenetic control, including well-studied targets such as the bromodomain-containing BET family of proteins and histone methyltransferase EZH2, the SGC has expanded to include chemical probes for other research areas, including kinases, serine proteases and other protein families. 

Chemical Probes

The SGC is a non-profit organization that partners public and private entities with the goal of conducting open-access research with relevance to drug discovery, placing a primary focus on elucidating the 3D structures of human protein and human parasite protein targets. Approximately 200 scientists from the Universities of Oxford and Toronto and nine pharmaceutical companies work to achieve this goal, making the structures, reagents and methods available to the public to facilitate further research on protein targets. 

Target Validation Using Chemical Probes

Backed by full characterization data from the SGC and the consistency and high quality of our Bioactive Small Molecule portfolio, SGC chemical probes allow you to validate your target with confidence. Explore the full offering of SGC chemical probes, including probes for bromodomains, methyltransferases, kinases, and other epigenetic targets.

Products

bioactive small molecules (66)

inhibitors (41)

probes (9)

antagonists (2)

cell biology (22)

cell signaling and structure BSM (9)

neuroscience (2)

powder (65)

solid (1)
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Showing 1-20 of 66
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Showing 1-20 of 66
(+)-JQ1
SML1524

(+)-JQ1

≥98% (HPLC), powder, BET bromodomain protein inhibitor

BAY-876
SML1774

BAY-876

≥98% (HPLC), powder, GLUT1 inhibitor

GSK343
SML0766

GSK343

≥98% (HPLC),  histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor, powder

GSK484
SML1658

GSK484

≥98% (HPLC), PAD4 inhibitor, powder

GSK-J4
SML0701

GSK-J4

≥98% (HPLC), jumonji H3K27 demethylase inhibitor, powder

A-485
SML2192

A-485

≥98% (HPLC), catalytic p300/CBP inhibitor, powder

IOX2
SML0652

IOX2

≥98% (HPLC), prolyl hydroxylases inhibitor, powder

(+/-)-JQ1
SML0974

(+/-)-JQ1

≥98% (HPLC), Brd4 inhibitor, powder

GSK-LSD1
SML1072

GSK-LSD1

≥98% (HPLC), lysine specific demethylase 1 (LSD1) inhibitor, powder

NVS-PAK1-1
SML1867

NVS-PAK1-1

≥98% (HPLC)

UNC1999
SML0778

UNC1999

≥98% (HPLC), EZH2 and EZH1 lysine methyltransferases inhibitor, powder

SGC0946
SML1107

SGC0946

≥98% (HPLC)

A-395 hydrochloride
SML1923

A-395 hydrochloride

≥98% (HPLC)

(-)-JQ1
SML1525

(-)-JQ1

≥95% (HPLC)

IOX1
SML0067

IOX1

≥97% (HPLC)

UNC0642
SML1037

UNC0642

≥98% (HPLC)

FM-381
SML1979

FM-381

≥98% (HPLC)

I-CBP112
SML1134

I-CBP112

≥98% (HPLC)

PFI-1
SML0352

PFI-1

≥98% (HPLC)

I-BRD9
SML1534

I-BRD9

≥98% (HPLC)

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