5.33574

TRPML3 Activator, ML123

• Synonym(e): TRPML3 Activator, ML123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
• Empirische Formel (Hill-System): C₁₆H₂₃ClN₂O₃S
• CAS-Nummer: 384352-24-3
• Molekulargewicht: 358.88
• MDL number: MFCD02172356
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 2911646
• Assay: ≥92% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥92% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: C1CCC(C(C1)NS(=O)(=O)C2=CC=C(C=C2)Cl)N3CCOCC3
• InChI key: AYQCZQKMGKDZPS-UHFFFAOYSA-N

Beschreibung

General description

A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC₅₀ = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC₅₀ = 31 µM).

Biochem/physiol Actions

Primary Target
TRPML3

Reversible: yes

Cell permeable: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395.

Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol.17, 135.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Gefahrencodes: H315,H319,H335