8.56186

Fmoc-Lys(ivDde)-Wang resin (100-200 mesh)

Novabiochem^®

• Synonym(e): Fmoc-Protected Lysine Resin
• NACRES: NA.22
• UNSPSC Code: 12352209

Eigenschaften

• Quality Segment: 200
• form: beads
• manufacturer/tradename: Novabiochem^®
• functional group: Fmoc
• storage temp.: 2-8°C

Beschreibung

General description

Useful tool for the synthesis of side-chain modified, cyclic and branched peptides by Fmoc SPPS. Following chain extension, the side-chain ivDde group is removed with 2% hydrazine in DMF, enabling selective modification of the ε-lysine amino group.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
SelectingOrthogonal Building Blocks

Literature references:
^[1] R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603.

Application

Fmoc-Lys(ivDde)-Wang resin (100-200 mesh) has been used as a solid support to prepare a peptide bearing a hexacarbonyldiiron cluster, neoglycopeptides and lipopeptides as putative antifungal and cancer vaccines, respectively.

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene -1 % DVB), 100- 200 mesh.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable